Aim. To establish the incidence of tumors of the central nervous system (CNS) in the population of Labin area in Istria,
Croatia, characterized by very little population migration.
Method. We retrospectively analyzed data on 175 patients (102 men and 73 women) diagnosed with CNS tumor according
to the World Health Organization’s diagnostic criteria in the period 1974-2001. Patient data were retrieved
from multiple sources: files of general practitioners in Labin area; registers of admissions and discharges of the Pula
General Hospital and Rijeka University Hospital Center; and medical records of the Hospital Departments of Neurology,
Surgery, Neurosurgery, Oncology and Radiotherapy, and Pathology. Annual incidence, anatomic location, and
pathohistological classification of CNS tumors were determined, as well as age at disease onset.
Results. Out of 175 subjects, 95 had primary CNS tumors and 80 had metastases. Intracranial tumors were found in
88.4% of patients with primary CNS tumors (annual incidence, 11.8/100,000 population) and intraspinal in 11.6% of
patients (annual incidence, 1.6/100,000). Similar distribution was observed for CNS metastases (70 intracranial vs 10
intraspinal), with annual incidence of 9.9 and 1.4/100,000, respectively. The most frequent intracranial tumors were
those of neuroepithelial tissue, accounting for 58.3% of all CNS neoplasms (annual incidence, 6.9/100,000 population).
The most frequent intraspinal tumors were tumors of the meninges (54.5%). There was no particular temporal
clustering of CNS tumors. The age at disease onset corresponded with that reported in the literature: 50.5±17.0 years
for primary intracranial tumors, and 59.7±12.2 years for primary intraspinal tumors.
Conclusion. Primary CNS tumors showed high, but temporally stable incidence in population of Labin area over the
last 27 years, indicating that the alleged increase in CNS tumors incidence was not true.