The foremost objective of this paper is to investigate the various determinants of self-employment in Pakistan, considering primary source of data at the district level. The sample of 494 workers residing in Bahawalpur district has been interviewed. We have employed Logistic Regression technique to estimate the determinants of self-employment model. The study concludes that experience and age of the workers have positive and significant impact on selfemployment. Moreover, educational attainment and good health variables have also significant and positive influence on workers’ decision to be self-employed. Based on the results and discussions, study suggests that government should provide technical and agricultural education at basic and secondary level to the workers. It is also concluded that health facilities should be provided at the massive scale particularly in rural areas.