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Citation Information

Type Journal Article - Journal of Clinical Virology
Title High prevalence of HTLV-I infection in Mashhad, Northeast Iran: a population-based seroepidemiology survey
Volume 52
Issue 3
Publication (Day/Month/Year) 2011
Page numbers 172-176
URL http://www.mums.ac.ir/shares/arc/arc/articl/2011/High prevalence of HTLV-I infection in Mashhad,​Northeast Iran.pdf
Background: Mashhad, in the northeast of Iran has been suggested as an endemic area for human T cell
lymphotropic virus type I (HTLV-I) infection since 1996.
Objectives: We performed a community-based seroepidemiology study to examine the prevalence and
risk factors for HTLV-I infection in the city of Mashhad.
Study design: Between May and September 2009, overall 1678 subjects from all the 12 geographical
area of Mashhad were selected randomly by multistage cluster sampling for HTLV antibody. The study
population included 763 males and 915 females, with the mean age of 29.1 ± 18.5 years. 1654 serum
samples were assessed for HTLV antibody using ELISA and reactive samples were confirmed by Western
blot and PCR.
Results: The overall prevalence of HTLV-I infection in whole population was 2.12% (95% CI, 1.48–2.93)
with no significant difference between males and females (p = 0.093) and the prevalence of HTLV-II
seropositivity was 0.12% (95% CI, 0.02–0.44).
The HTLV-I Infection was associated with age (p < 0.001), marital status (p < 0.001), education
(p = 0.047), and history of blood transfusion (p = 0.009), surgery (p < 0.001),traditional cupping (p = 0.002),
and hospitalization (p = 0.004). In logistic regression analysis, age was the only variable that had a significant
relation with the infection (p = 0.006, OR = 4.33).
Conclusions: Our results demonstrated that Mashhad still remains an endemic area for HTLV-I infection
despite routine blood screening. Thus, further strategies are needed for prevention of the virus
transmission in whole population.

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