Smoking-attributable deaths and years of potential life lost were estimated using the formula adopted to estimate UK and US deaths caused by smoking. These estimates are based on sex-specific proportions by age of current and ex-smokers and rates of relative risk. For prevalence data we used data of 2010 STEPS survey in Georgia and Georgia Reproductive Health Survey 2005. Relative risks for potentially fatal diseases due to smoking are those that were used to estimate UK 1995 deaths. They were derived from years 1984-1988 of the Cancer Prevention Study II (CPS II). Smoking attributable mortality was estimated for year 2008, period when registration of deaths was done by adopted methods and institutions. By the calculations according to mortality data of year 2008 number of active smoking attributable deaths were 4331. Smoking is related with 10,1% of all deaths. By causes of death smoking attributed is 30% of all deaths caused by cancers, 10% of cardiovascular diseases, 9% of respiratory and 7% of digestive diseases. About 72500 potential years of life is lost in Georgia during year 2008 due to active smoking. Great majority of this burden is related with cardio vascular diseases and cancers.