Background: Substance abuse in adolescents and its often tragic consequences, including addiction, is one of the pre- ventable major public health problems. The aims of this paper were to estimate the prevalence of substance abuse and
to evaluate its some associated factors in adolescents of Tabriz City (northwest of Iran).
Methods: A self-administered questionnaire was completed in 4903 randomly selected students with mean age of 15.7
years old. The aim of the questionnaire was obtaining information on substance abuse, socio-economical information,
cigarette smoking behavior, general risk taking behavior, self-esteem, attitude towards smoking and self-injury as well
as demographical characteristics.
Results: Prevalence of substance abuse was 1.4% (95% CI: 1.1–1.7) which was different statistically significant between
boys (2.4%) and girls (0.6%) (P<0.001). Older age (OR=1.43), not living with parents (OR=2.34), having gen- eral risk taking behavior (OR=2.26), higher smoking stage (OR=2.39), lower self-esteem (OR=1.09) and positive attitude
toward smoking (OR=1.08) were factors associated with student's ever use of substance.
Conclusion: The result has shown low prevalence of substance abuse in Iranian adolescents. Our findings showed
some associated factors such as lower self-esteem with adolescent’s substance abuse