Seroprevalence of poliovirus antibodies among 7-month-old infants after 4 doses of oral polio vaccine in Sistan-va-Baluchestan, Islamic Republic of Iran

Type Journal Article - Eastern Mediterranean Health Journal
Title Seroprevalence of poliovirus antibodies among 7-month-old infants after 4 doses of oral polio vaccine in Sistan-va-Baluchestan, Islamic Republic of Iran
Author(s)
Volume 21
Issue 2
Publication (Day/Month/Year) 2015
Page numbers 83-89
URL http://www.nitag-resource.org/uploads/media/default/0001/02/a7b031912aa98dd56a3c640b2e9a5b23836e37ec​.pdf
Abstract
Despite high coverage rates of polio vaccine in the Islamic Republic of Iran, the seroconversion rates of
infants may be inadequate. This study measured seroprevalence of antibodies against poliovirus serotypes 1 to 3 (PV1,
PV2 and PV3) in 7-month-old infants who had received at least 4 doses of trivalent oral polio vaccine. A serosurvey
was conducted in 2010 in rural areas of Chabahar, Sistan-va-Baluchestan province. Using cluster sampling, 72 eligible
infants were tested for antibody against the 3 poliovirus serotypes according to WHO guidelines. Antibody titres = 1:10
were considered positive. The seropositive rates for antibody against PV1, PV2 and PV3 were 84.7%, 95.8% and 70.8%
respectively. Only 63.9% of participants were seropositive for antibodies against all 3 poliovirus serotypes. Except
for PV2, the seroprevalence of antibody against the other 2 poliovirus serotypes, especially PV3, was unsatisfactory.

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