Water quality of different sources of water (stream, borehole and pipe born water) in the Niger Delta region of Nigeria was evaluated by Water Quality Index (WQI) technique. The present investigations was carried out to compute the Water Quality Index (WQI) in order to assess the suitability of water from different sources collected from different areas in the Niger Delta region of Nigeria. In this study, WQI was determined on the basis of various physico-chemical parameters like pH, total alkalinity, chlorides, sulphate, nitrate, total hardness, calcium, magnesium, electrical conductivity, dissolved oxygen, biochemical oxygen demand, total dissolved solids and total suspended solids. The results obtained for the WQI from the different sampling stations were found to be varied from 34.80 to 36.26 for pipe borne water, 38.52 to 48.67 for borehole water and 55.05 to 84.94 for stream water. The results indicate that the different water samples analysed from pipe born and borehole water are safe for safe for human consumption and for other domestic purposes while the samples analysed from stream water are not safe for human consumption.