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Type Journal Article - Annals of Punjab Medical College
Title Incidence of ß-thalassemia Carriers in Muzaffarabad, Azad Kashmir
Author(s)
Volume 10
Issue 1
Publication (Day/Month/Year) 2016
Page numbers 11-19
Abstract
Objective: To determine the frequency of ß-thalassemia carriers in healthy population from Muzaffarabad Azad
Kashmir. Methods: In this cross sectional population based study, people from Muzaffarabad were motivated to get
themselves tested for beta thalassemia trait. People found healthy on basis of a questionnaire and clinical examination
were included in the study. Complete blood counts and peripheral smear review were performed on EDTA samples.
Hemoglobin (Hb) electrophoresis was performed. Subjects with mean corpuscular volume (MCV), <76 fl, and/or mean
corpuscular Hb (MCH), < 27 pg were subjected to hemoglobin A2 (HbA2) level estimation by elution method.
Hemoglobin A2 of more than 3.5% was considered diagnostic for beta-thalassemia trait. Azad Kashmir is a territory with
considerable ethnic heterogeneity. This is basically a tribal society with a high proposition of consanguineous marriages.
We created awareness among the general population. Results: Found that gene is present in almost all tribes studied.
Conclusion; - Using strict criteria for healthy population, we conclude that incidence of thalassemia trait is 5.6 % in our
study population. ß -thalassemia trait is present in almost all ethnic groups. To control thalassemia major, screening
program for thalassemia carriers must be initiated in the area

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