Testing a new formulation for Peste des Petits Ruminants vaccine in Ethiopia

Type Journal Article - Vaccine
Title Testing a new formulation for Peste des Petits Ruminants vaccine in Ethiopia
Volume 32
Issue 24
Publication (Day/Month/Year) 2014
Page numbers 2878-2881
URL https://www.infona.pl/resource/bwmeta1.element.elsevier-956e386a-6139-3891-ab12-0212cd309155
In this paper extended tests on a new candidate formulation for Peste des Petits Ruminants (PPR) vaccine
carried out at National Veterinary Institute (NVI) in Ethiopia are presented. This work was performed in
the frame of the VACNADA project from GALVmed which aimed at procuring vaccines against neglected
veterinary diseases to African vaccine producing laboratories, in particular PPR.
After the eradication of Rinderpest, Peste des Petits Ruminants became the next veterinary disease
on target for elimination, requiring an effective and thermostable vaccine. In this work a Tris/Trehalose
formulation was evaluated in thermal stability studies in comparison to the current used formulation of
the live attenuated PPR vaccine, the Weybridge medium. The extended results presented herein show
an increased thermal stability of the vaccine, especially at 37 and 45 ◦C, as expected from previously
published results (Silva A.C. et al., 2011). Furthermore, during the course of this project, the NVI teams
have clearly demonstrated ability to produce higher quality PPR vaccines after a successful transfer of
the technology. These results should significantly enhance the utility of the vaccine in the eradication of

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