A survey of 170 Liberians was conducted through a partnership between Rust College in Mississippi, USA and Cuttington University, Liberia, funded by the United Negro College Fund Special Programs (UNCFSP) in 2006. Data were gathered on respondents’ socio-economic characteristics, alcohol use, and sex life; awareness of HIV/AIDS; knowledge of HIV/AIDS; sources of information about HIV/AIDS; beliefs, attitudes and behavior; opinions related to sexual practices; awareness of condom; and, access to media and acceptance of message on safe sex. The study findings showed that, on the whole, the levels of awareness of HIV/AIDS, knowledge of its origins and knowledge of preventive behaviors appeared to be considerably higher than their level of protective behaviors for safe sex—i.e., their knowledge and awareness did not change significantly their risky behavior. These findings suggest that there is a critical need for capacity building and implementation of effective HIV/AIDS prevention strategies to overcome negative health related consequences, including dissemination, intervention and evaluation associated with the risk of contracting and spreading HIV/AIDS in Liberia