Health status at older ages around the globe has changed due to changes in epidemiological environment, diet and nutrition, medical technology and public and individual health practices. However, the change is likely to vary across countries with different economic, epidemiological, and policy circumstances. Using 2 waves of nationally representative datasets from five countries with varying income levels, we examine changes in biological risk in U.S., England, Mexico, Taiwan and Indonesia. Biological risk factors include systolic and diastolic blood pressure, BMI, Total and HDL cholesterol, and glycated hemoglobin. Our analysis includes respondents age 50+ who participated in physical examination and blood collection. We find that patterns of age-specific onset of high-risk levels of biological risk vary across countries. No single country has the highest or lowest onset levels for all biological risk factors. A relatively low-income country, Indonesia, has the highest onset rates for high blood pressure, though its rate of onset of overweight is the lowest; while the high-income countries such as U.S. and England had higher onset rates of overweight than other countries, their onset rates of high blood pressure tend to be lower. The U.S. had fairly high levels of onset of high HbA1c; while England had relatively high levels of increase in high cholesterol. Our findings indicate different levels of onset of biological risk across countries with different income.