Anemia in pregnancy is a common public health problem and associated with high rates of mortality and
morbidity in pregnant women as well as perinatal mortality. It is crucial to identify risk factors of prenatal
anemia so interventions can be designed to address them. The aim of this study is to determine factors
associated with anemia in pregnancy in Yilo Krobo Municipality. An unmatched case-control study was
conducted among 110 (55 cases and 55 controls) pregnant women attending antenatal clinics in health facilities
in the Municipality from June to December 2012. Socio-demographic, antenatal, infective and dietary data of
study participants were collected using structured questionnaires. Data were analyzed using Epi Info 3.5.4.
Bivariate and multivariate analyses were computed. Bivariate analysis shows a positive association between
having prenatal anemia and having no formal education (OR-2.6, p-value 0.04), increased in birth spacing more
than 5years (OR-3.06 p-value 0.029), herbal medicine intake (OR-4.0 p-value 0.008), parity of more than three
children (OR-2.9, p-value 0.01) and owning insecticide treated nets (OR-0.359, p-value 0.023). Multivariate
analysis shows significant association between herbal medicine intake (OR-3.14, p-value 0.031) and prenatal
anemia. Prenatal anemia is therefore significantly associated with herbal medicine intake during pregnancy.