In a recent report, Norrington-Davie (2015) declared that climate change is not a priority for the Government of Cameroon and is unlikely to become so in the near future as Cameroon focuses on improving job creation and reducing widespread poverty. According to the author, awareness of climate change, both inside and outside of government, is largely limited to an understanding of environmental and climate related impacts at the local levels. Higher level political commitment for climate change is limited and there is currently no capacity within line ministries to mainstream climate change across sector programmes. A National Observatory for Climate Change (ONACC) is expected to address some of these issues but its creation has been pending since the issuance of a Presidential Decree in December 2009 (Norrington-Davies, 2015). This paper aims at assisting the Cameroonian government in meeting the sustainable millennium development goals through adaptation with the focus on Climate change in agriculture. The first part of the paper highlights the issue of climate change developments in Cameroon. The second part sheds light on the literature review by revisiting some concepts around climate change mitigation in the Cameroonian agriculture sector. The third part develops the roadmap in dealing with climate change challenges in Cameroon. The last gives recommendations regarding adaptation on climate change in Cameroon.