In today’s modern evolving business environment, climate change has become an issue of concern. Because of the extreme climatic manifestations in many parts of the world, climate change has been drawn to the centre of most discussions not only in business circles, but also in academic settings. In the case of Cameroon, unfortunately awareness of climate change, both inside and outside the government, is largely limited to an understanding of environmental and climate related impacts at the local levels. Daily news worldwide highlight limited level of political commitment for climate change, and the recent decision of the US president to pull out his country out of the Paris agreement on climate change mitigation is an illustration. In the case of Cameroon, there is currently no capacity within ministries to mainstream climate change across sector programmes. A National Observatory for Climate Change (ONACC) is expected to address some of these issues. This paper aims at assisting the Cameroonian government in meeting the challenge on sustainable development goals through adaptation in agriculture. The first part of the paper highlights the crucial problem of climate change development in Cameroon. The second part sheds light on the literature review by revisiting some concepts around climate change mitigation in the agriculture sector. The third part develops the roadmap in dealing with climate challenges in Cameroon, and the last part come up with recommendations regarding adaptation in agriculture in Cameroon.