This research was carried out to study climate change and its impacts on major crops production in Khotang district of Nepal. The effect of climate variables on crops yield and farmers` respond to climate change in the last eight to ten years were studied and analyzed. Monthly precipitation data in Aiselukharka, Kuruleghat, Khotangbajar and Diktel; and monthly minimum and maximum air temperatures data in Okhaldhunga, Chainpur East and Udayapur Gadhi available from the Department of Hydrology and meteorology in Nepal were used to study their annual and seasonal trends. Time-series annual yield data in maize, paddy, wheat, millet and potato were collected from the District Agriculture Development Office Khotang. The linear trends in various sites were computed to study the climate variations whereas multiple regressions were used to study the relationships between climate variables and crop yields. Focal group discussions, key informants interviews, household survey and field observations were carried out in Bamrang Khola micro-watershed in Khotang district as an empirical survey.