Tanzania, one of many nations in Africa with high infant mortality to preventable diseases, continues to experience relatively low vaccination rates for childhood diseases. In this paper, we examine the maternal barriers to obtaining vaccines for their children in Tanzania. The risk and protective factors we analyzed include age of the mother and children, education level of the mother, number of children, maternal decision-making practices, power dynamics and others. Lack of control, limited decision practices, and decreased maternal empowerment were identified as key barriers to obtaining vaccines for children. Overall, this data is consistent with previous studies regarding barriers to vaccinations in Tanzania and other African nations.