The proposed paper intends to discuss the Aral Sea Environmental crisis in Central Asia and its impact on human health. The Aral Sea crisis in Central Asia is one of the biggest man- made Human disaster and ecological disasters in the world. After the disintegartion of Soviet Union, the Aral Sea water environmental challenges turned as a global challanges, when Central Asia beccame independent states its unable to solve this issues without global assistance. Aral Sea was the fourth largest source of water on earth, It was around 66,000 km2. However, the developmental human activities caused the aridness of Sea and water crisis in the basin. The destruction of the sea and its ecosystems as a result of cotton monoculture constitutes one of the greatest man-made environmental disasters in history. Various dimensions of Aral Sea crisis are well documented. However, the health impact of environmental disaster generated by Aral Sea crisis is an under-researched area exploring the health aspects in human security perspective provides a different view about the crisis and human tragedy it created in contemporary Central Asia. This paper focus mainly on the impact of environmental crisis on human health in five Central Asian states of Kyrgyzstan, Kazakhstan, Uzbekistan, Turkmenistan, Tajikistan. And discuss about Environmental disaster, Environmental Degradation, Water Crisis, Climate change, Water Scarcity, Salinity, Desertification and Land Degradation in Central Asia. All these issues create human insecurity in Central Asia and as a result human health gets affected in this region.