|Type||Journal Article - The Journal of Infection in Developing Countries|
|Title||Clinical and virological response to antiretroviral drugs among HIV patients on first-line treatment in Dar-es-Salaam, Tanzania|
Introduction: In Tanzania, the follow-up on antiretroviral therapy (ART) response is based on clinical outcomes. We investigated virological
response and ARV resistance mutations in relation to clinical response in ARV-treated patients.
Methodology: A cross-sectional study of a cohort of 150 patients taking first-line ART in Dar-es-Salaam was conducted. Data were collected
using standardized questionnaires and patients’ blood samples. HIV viral load testing and genotyping was performed on all viremic samples.
Statistical analyses compared clinical responders and non-responders.
Results: The median time on ART was 20 months; 71 (47%) patients were ART clinical responders. Clinical non-responders were more
likely to have started ART with advanced disease with significantly lower median percentage weight gain (6% versus 20%) with respect to
pre-treatment levels. Sixty-one (86%) and 64 (81%) of clinical responders and non-responders, respectively, had undetectable viral loads.
Genotyping was successful in 24 (96%) virologically failing patients, among whom 83% had resistance mutations; 67% had dual nucleoside
reverse transcriptase inhibitor (NRTI)/non-NRTI (NNRTI) resistance mutations. Seventeen (71%) and 19 (79%) patients had NRTI and
NNRTI resistance mutations, respectively, which were related to the ART in use, with no difference between clinical responders and nonresponders.
The most prevalent subtypes were A and C, found in 9 (38%) and 7 (29%) patients, respectively.
Conclusions: The observed virological response was high and did not correlate with clinical response. The prevalence of ARV resistance
mutations was high in viraemic patients and was related to the ARV prescribed. We recommend use of viral load monitoring during ART in
|»||Tanzania - Population and Housing Census 2012|