This study investigates the factors affecting agricultural production of farm households in the National Regional State of Tigray, Ethiopia. The major primary sources of data for the study were farm household surveys, focus group discussions and key informant interviews. The study revealed that the annual average crop production of respondents was found to be below the standard annual food requirement recommended by the international organizations. The proportion of irrigated land to total cultivated land was only 11per cent. The proportion of irrigated land in the two districts is lower than 11.27 per cent at the regional level. The utilization of chemical fertilizers for the majority of the respondents was below the recommended standard for the region. Although the farmers were interested in using improved seeds, the supplied varieties were not based on their preferences. Extension agents were mainly engaged in activities which were not related to their professions. The farm income model result showed that landholding size (p<0.0001), possession of oxen(p<0.0001), amount of fertilizer(p=0.010), improved seeds(p=0.002), irrigation(p=0.028), soil quality(p=0.019), village distance to the district market(p=0.066), average distance of plots from the homestead (p=0.023) and crop rotation(p=0.016) were determinant variables. Farmers were engaged in off-farm activities to fulfill the cash requirements in credit constrained conditions. The laws of the region do not allow farmers to be out of their localities for more than two years and the farmerswere restricted to renting out only half of their land. This discouraged farmers from off-farm participation for fear of land confiscation. In the Probit model, the determinant variables of off-farm participation were: irrigation (p=0.001), age (p=0.007), amount of money borrowed (p=0.078), village distance to the wereda market (p=0.055), fear of land confiscation (p=0.023) and access to electricity (p=0.044). It is recommended that if farmers are to use chemical fertilizers, they should be supplied with High Yielding Varieties (HYV)and enough water through access to irrigation. Furthermore, farmers should be allowed to have long term off-farm employment to augment the farming sector.