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Citation Information

Type Journal Article - Acta Psychiatr Scand
Title Clinical Outcome in Bipolar Disorder in a Community-based Follow-up Study in Butajira, Ethiopia
Volume 114
Publication (Day/Month/Year) 2006
Page numbers 426-434
URL https://www.researchgate.net/profile/Derege_Kebede/publication/6708928_Clinical_outcome_in_bipolar_d​isorder_in_a_community-based_follow-up_study_in_Butajira_Ethiopia/links/548039cd0cf250f1edbfcab1.pdf
Objective: To determine the clinical outcome of bipolar disorder in a developing country setup. Method: After assessing 68 378 individuals, aged 15–49 years, in a double-sampling design in a rural community in Ethiopia, 312 patients with bipolar disorder were prospectively monitored with symptom rating scales and clinically for an average of 2.5 years. Results: Overall, 65.9% of the cohort experienced a relapse – 47.8% manic, 44.3% depressive and 7.7% mixed episodes – and 31.1% had persistent illness. Female gender predicted depressive relapse, while male gender predicted manic relapse. Being on psychotropic medication was associated with remission. Conclusion: This large community-based study confirms the relapsing nature of bipolar disorder and a tendency for chronicity. This may be partly because of lack of appropriate interventions in this setting; however, it may also indicate the underlying severity of the disorder irrespective of setting.

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