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Citation Information

Type Journal Article - West Indian Medical Journal
Title Seroprevalencia del Trypanosoma cruzi en los donantes de sangre en el Servicio Nacional de Transfusion de Sangre en Guyana
Volume 61
Issue 6
Publication (Day/Month/Year) 2012
Page numbers 559-563
URL http://caribbean.scielo.org/scielo.php?script=sci_arttext&pid=S0043-31442012000600002&lng=es&nrm=iso​?ref=HadiZayifla.Com
INTRODUCTION: Blood transfusion is an important transmission route of Trypanosoma cruzi (T cruzi), a major parasitic infection in Central and South America. The limited treatment options are most effective in acute Chagas' infection. At present, there is no current data on the prevalence of T cruzi in the blood donor population of Guyana. This information is necessary to protect the supply of the blood donation programme.
This study sought to determine the prevalence of T cruzi in the blood supply at the National Blood Transfusion Services of Guyana with the hope of providing knowledge to the on-going surveillance for Chagas' disease worldwide and therefore address the risk of its spread by blood transfusion.
METHODS: Two commercialized ELISAs utilizing crude or recombinant T cruzi antigens were used to study 2000 blood samples voluntarily donated for the purpose of altruistic or family replacement donation retrospectively.
RESULTS: The results showed that approximately 1 in 286 donations tested positive for antibodies to T cruzi.
CONCLUSION: These results indicate that T cruzi continues to be a risk in Guyana and there is a need to continue screening donated blood. Trypanosoma cruzi is a life-long infection and infected persons may be asymptomatic chronic carriers of the disease. Education, housing improvement, and controlled use of insecticides should be introduced to contain Chagas' disease.

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