The purpose of this study was to explore the knowledge and awareness about cancer among the less privileged population’ in Jordan. A cross-sectional design with stratified random sampling method was used to select the participants. Jordan is composed from 12 governorates, all of them were included in the study except the capital. A representative sample of 1,717 adults have completed the study interview. The participants’ mean age was 37.6 years. The majority of participants in this study belief that cancer care in Jordan is expensive. One-third of the participants perceived the diagnosis of cancer with social stigma. The socioeconomic status as reflected by education and income levels revealed lower ratios in the sample of the study in comparison to other studies. In conclusion, the results suggest the need for additional studies tailored to each geographical area to explore its population specific awareness and needs toward cancer.