A cross-sectional study was conducted in and around Dire Dawa Provisional Administrative Council
(DDPAC) from November, 2011 to March, 2012 to determine the seroprevalence of contagious caprine
pleuropneumonia (CCPP) and to assess risk factors associated with seropositivity. In this study, 244
sera were collected from goats and subjected to complement fixation test. Out of the total sera tested,
12 (4.92%) were positive for CCPP. The seroprevalence of CCPP was significantly (P < 0.05) higher in
adult (7.38%) than in young (1.05%) goats. There was non-significant variation with regards to the risk
involvement of she-goat (4.67%) and buck (5.32%) in the flock, irrespective to the low and mid agroclimatic
zones. Husbandry practices were found to play a significant role on the seroprevalence of
CCPP as revealed in semi-intensive (13.64%) than in extensive (4.05%) husbandry system. Moreover,
higher seroprevalence in large flock established significant contagiousness than in small flock size. In
conclusion, this study indicated that CCPP is still prevalent in DDPAC region of Eastern Ethiopia, which
may underlines the importance of further studies and implementation of appropriate preventive and
control measures.