Introduction: Traditional Medicine is a widely and rapidly growing health system with economic importance. Globally, about 20-80 percent of the world’s population uses various forms of alternative medication and medicine. AIM: This study was carried out to assess the prevalence and socio-demographic determinants of combined orthodox and traditional medicine use among households in Imo State, Nigeria. Methodology: This was a cross-sectional descriptive study conducted among 422 participants selected from households in communities from orlu, Imo State, using the multi stage random sampling. A semi-structured, pretested, interviewer administered questionnaire was used to collect information from the participants and data was analyzed using EPI INFO version 7.1. A p-value of less than 0.05 was considered significant. Results: The prevalence of traditional medicine use and orthodox and traditional medicine combination was 77.5% and 63.7% respectively. Most, (86.3%) of the participants preferred orthodox medicine over traditional medicine and their commonest reason for preference is that it was more effective, (68.2%). Socio-demographic and household characteristics that significantly influenced combined utilization of both when sick were; age, sex, marital status, educational status, occupation, household size, family size, death of an under-five in the last one year, and the cause of death of the under-five, (p=<0.05). Conclusion: Our study revealed high use of both traditional medicine and the combination of both. There is need to increase awareness especially to the target groups on the likely dangers associated with combined use of orthodox and traditional medicine.