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Citation Information

Type Thesis or Dissertation - Master in Medicine in Internal Medicine
Title Seroprevalence of Cryptoccocal Antigenemia in HIV positive adult inpatients with severe immunosuppresion attending the Kenyatta National and Mbagathi Hospitals
Author(s)
Publication (Day/Month/Year) 2013
URL http://erepository.uonbi.ac.ke/bitstream/handle/11295/59604/Muchiri_Seroprevalence of cryptoccocal​antigenemia in HIV positive adult inpatients with severe immunosuppresion.pdf?sequence=3
Abstract
Background
In the world and especially Sub Saharan Africa (SSA), HIV is a leading public health concern.
Cryptococcal meningitis (C.M) is the 2nd leading opportunistic infection and is an AIDS defining
illness associated with high morbidity and mortality despite the use of HAART and effective
anti-fungal treatment. Screening for cryptococcal antigenemia with the use of pre-emptive
antifungal therapy may reduce the burden of disease in populations with a high prevalence of
cryptococcal antigenemia. The prevalence of cryptococcal antigenemia in Nairobi Kenya has not
been established.
Objectives
To determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected
adult in-patients HAART naïve with low CD4 counts, at the KNH and Mbagathi hospitals.
Study design and settings
Cross sectional descriptive study that was carried out at Kenyatta National and Mbagathi
hospitals’ in-patient medical wards.
Methods
A total of 196 HIV ELISA positive adult patients HAARTnaïve, with a CD4 of ≤100 cells/µl
admitted to the medical wards were consecutively recruited. Their demographic data was
captured using a pretested structured questionnaire and were clinically evaluated for WHO
clinical staging and symptoms or signs of meningitis. All participants had a serum CRAG
assessment and CD4 count done using lateral flow assay, an ELISA method and CyFlow
respectively. Prevalence of CRAG serum positivity was ascertained. Association of seropositivity
to the demographic, laboratory and clinical characteristics was determined using Chisquare
and Student’s T-test. P Value of less than 0.05 was considered significant.
Results
The seroprevalence of cryptococcal antigenemia was 13.8%. On bivariate analysis cryptococcal
antigenemia was associated with neck stiffness. OR 3.9 (1.4-10.7, 95% CI)
Seropositivity was not related to other demographic and clinical factors.
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Conclusion
The seroprevalence of cryptococcal antigenemia is high in this population.

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